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Article

IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.

PloS one - 1 Jan 2015

Dhyani Ashish, Tibolla Gianpaolo, Baragetti Andrea, Garlaschelli Katia, Pellegatta Fabio, Grigore Liliana, Norata Giuseppe Danilo, Catapano Alberico Luigi

Abstract excerpt

Inducible degrader of the low density lipoprotein receptor (IDOL), is an E3 ubiquitin ligase that negatively modulates low density lipoprotein receptor (LDL-R) expression. Genome-wide association studies (GWAS) indicated that genetic variants in IDOL gene contributes to variation in LDL-C plasma levels and the detailed analysis of a specific locus resulted in the identification of the functional common single...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25927920
DOI: 10.1371/journal.pone.0122414
PMCID: PMC4415795

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.PMID 25927920Read ↗

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