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Article

The LDL receptor-related protein (LRP1/A2MR) and coronary atherosclerosis--novel genomic variants and functional consequences.

Human mutation - 1 Nov 2002

Schulz Susanne, Schagdarsurengin Undraga, Greiser Petra, Birkenmeier Gerd, Müller-Werdan Ursula, Hagemann Monika, Riemann Dagmar, Werdan Karl, Gläser Christiane

Abstract excerpt

The LDL receptor-related protein/alpha 2-macroglobulin receptor (LRP1/A2MR) is a multifunctional cell-surface glycoprotein that endocytoses several structurally and functionally distinct ligands. In clinical studies different genomic variants of the LRP1/A2MR and its role in the development of degenerative diseases like atherosclerosis or Alzheimer's disease were studied. We screened for novel genomic variants of...

Topics

Adult
Coronary Artery Disease
Female
Genetic Predisposition to Disease
Genetic Variation
Genome, Human
Humans
Low Density Lipoprotein Receptor-Related Protein-1
Male
Monocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocardial Infarction

Polymorphism, Genetic

Promoter Regions, Genetic

RNA, Messenger

Source

Identifiers

PMID: 12402342
DOI: 10.1002/humu.9070

Genes

LRP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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