A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes.

doi:10.2337/db14-0742

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A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes.

Diabetes - 1 Aug 2015

Sluijs Ivonne, Holmes Michael V, van der Schouw Yvonne T, Beulens Joline W J, Asselbergs Folkert W, Huerta José María, Palmer Tom M, Arriola Larraitz, Balkau Beverley, Barricarte Aurelio, Boeing Heiner, Clavel-Chapelon Françoise, Fagherazzi Guy, Franks Paul W, Gavrila Diana, Kaaks Rudolf, Khaw Kay Tee, Kühn Tilman, Molina-Montes Esther, Mortensen Lotte Maxild, Nilsson Peter M, Overvad Kim, Palli Domenico, Panico Salvatore, Quirós J Ramón, Rolandsson Olov, Sacerdote Carlotta, Sala Núria, Schmidt Julie A, Scott Robert A, Sieri Sabina, Slimani Nadia, Spijkerman Annemieke M W, Tjonneland Anne, Travis Ruth C, Tumino Rosario, van der A Daphne L, Sharp Stephen J, Forouhi Nita G, Langenberg Claudia, Riboli Elio, Wareham Nicholas J

Abstract excerpt

We aimed to investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk. A Mendelian randomization study was performed using a genetic score with 24 uric acid-associated loci. We used data of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, comprising 24,265 individuals of European ancestry from eight European countries. During a...

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Identifiers

PMID: 25918230
DOI: 10.2337/db14-0742
PMCID: PMC6284788

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