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Article

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.

Redox biology - 1 Aug 2015

Sataranatarajan Kavithalakshmi, Qaisar Rizwan, Davis Carol, Sakellariou Giorgos K, Vasilaki Aphrodite, Zhang Yiqiang, Liu Yuhong, Bhaskaran Shylesh, McArdle Anne, Jackson Malcolm, Brooks Susan V, Richardson Arlan, Van Remmen Holly

Abstract excerpt

Our previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZnSOD, Sod1KO mice) have neuromuscular changes resulting in dramatic accelerated muscle atrophy and weakness that mimics age-related sarcopenia. We have further shown that loss of CuZnSOD targeted to skeletal muscle alone results in only mild weakness and no muscle atrophy. In this study, we targeted deletion of CuZnSOD...

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Identifiers

PMID: 25917273
DOI: 10.1016/j.redox.2015.04.005
PMCID: PMC5022075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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