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Article

mdx muscle pathology is independent of nNOS perturbation

1 May 1998

Abstract excerpt

In skeletal muscle, neuronal nitric oxide synthase (nNOS) is anchored to the sarcolemma via the dystrophin-glycoprotein complex. When dystrophin is absent, as in Duchenne muscular dystrophy patients and in mdx mice, nNOS is mislocalized to the interior of the muscle fiber where it continues to produce nitric oxide. This has led to the hypothesis that free radical toxicity from mislocalized nNOS may contribute to...

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PMID: 9536086
DOI: 10.1093/hmg/7.5.823

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