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Article

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 2001

Pramatarova A, Laganière J, Roussel J, Brisebois K, Rouleau G A

Abstract excerpt

Mutations were identified in the Cu/Zn superoxide dismutase gene (SOD1) in approximately 15% of patients with familial amyotrophic lateral sclerosis. Transgenic animals expressing mutant SOD1 in all tissues develop an ALS-like phenotype. To determine whether neuron-specific expression of mutant SOD1 is sufficient to produce such a phenotype, we generated transgenic animals carrying the G37R mutation that is...

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Identifiers

PMID: 11331366
PMCID: PMC6762496

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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