Article
Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice.
Aging cell - 1 Oct 2020
Bhaskaran Shylesh, Pollock Natalie, C Macpherson Peter, Ahn Bumsoo, Piekarz Katarzyna M, Staunton Caroline A, Brown Jacob L, Qaisar Rizwan, Vasilaki Aphrodite, Richardson Arlan, McArdle Anne, Jackson Malcolm J, Brooks Susan V, Van Remmen Holly
Abstract excerpt
Age-associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice (Sod1-/- mice) recapitulates sarcopenia phenotypes, including elevated oxidative stress and accelerated muscle atrophy, weakness, and disruption of neuromuscular junctions (NMJs). To determine whether deletion of Sod1 initiated in neurons...
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