Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice.

The Journal of physiology - 1 Dec 2023

Xu Hongyang, Czyżowska Agnieszka, Van Remmen Holly, Brown Jacob L

Abstract excerpt

Our laboratory previously showed lipid hydroperoxides and oxylipin levels are elevated in response to loss of skeletal muscle innervation and are associated with muscle pathologies. To elucidate the pathological impact of lipid hydroperoxides, we overexpressed glutathione peroxidase 4 (GPx4), an enzyme that targets reduction of lipid hydroperoxides in membranes, in adult CuZn superoxide dismutase knockout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Glutathione
Share to Glutathione Peroxidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Peroxide

Share to Lipids

Share to Sarcopenia

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 37878529
DOI: 10.1113/JP285259
PMCID: PMC10871152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice.PMID 37878529Read ↗

Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice.Semantic proximity Read ↗

Examining the implications of glutathione peroxidase 4 overexpression and its impact on sarcopenia phenotypes in mice.Semantic proximity Read ↗

Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.Semantic proximity Read ↗

Differential ferroptosis regulation in red and white gastrocnemius under obesity and its Attenuation by exercise and dietary restrictionSemantic proximity Read ↗

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.Semantic proximity Read ↗

PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice.Semantic proximity Read ↗

Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy.Semantic proximity Read ↗

PGC-1β prevents statin-associated myotoxicity in oxidative skeletal muscleSemantic proximity Read ↗

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.Semantic proximity Read ↗

Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.Semantic proximity Read ↗

A chemical chaperone improves muscle function in mice with a RyR1 mutation.Semantic proximity Read ↗

PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.