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Article

Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2014

Mori Taizo, Iwasaki Yukiko, Seki Yoichi, Iseki Masanori, Katayama Hiroko, Yamamoto Kazuhiko, Takatsu Kiyoshi, Takaki Satoshi

Abstract excerpt

Dendritic cells (DCs) are proficient APCs that play crucial roles in the immune responses to various Ags and pathogens and polarize Th cell immune responses. Lnk/SH2B adaptor protein 3 (Sh2b3) is an intracellular adaptor protein that regulates B lymphopoiesis, megakaryopoiesis, and expansion of hematopoietic stem cells by constraining cytokine signals. Recent genome-wide association studies have revealed a link...

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PMID: 25024389
DOI: 10.4049/jimmunol.1303243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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