Genome-scale strain designs based on regulatory minimal cut sets.

Abstract excerpt

MOTIVATION: Stoichiometric and constraint-based methods of computational strain design have become an important tool for rational metabolic engineering. One of those relies on the concept of constrained minimal cut sets (cMCSs). However, as most other techniques, cMCSs may consider only reaction (or gene) knockouts to achieve a desired phenotype. RESULTS: We generalize the cMCSs approach to constrained regulatory...

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