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Article

Robust mutant strain design by pessimistic optimization.

BMC genomics - 3 Oct 2017

Apaydin Meltem, Xu Liang, Zeng Bo, Qian Xiaoning

Abstract excerpt

BACKGROUND: Flux Balance Analysis (FBA) based mathematical modeling enables in silico prediction of systems behavior for genome-scale metabolic networks. Computational methods have been derived in the FBA framework to solve bi-level optimization for deriving "optimal" mutant microbial strains with targeted biochemical overproduction. The common inherent assumption of these methods is that the surviving mutants...

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PMID: 28984191
DOI: 10.1186/s12864-017-4025-7
PMCID: PMC5629566

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