Article
Evolutionary programming as a platform for in silico metabolic engineering.
BMC bioinformatics - 23 Dec 2005
Patil Kiran Raosaheb, Rocha Isabel, Förster Jochen, Nielsen Jens
Abstract excerpt
BACKGROUND: Through genetic engineering it is possible to introduce targeted genetic changes and hereby engineer the metabolism of microbial cells with the objective to obtain desirable phenotypes. However, owing to the complexity of metabolic networks, both in terms of structure and regulation, it is often difficult to predict the effects of genetic modifications on the resulting phenotype. Recently genome-scale...
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