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Article

BST2/Tetherin Inhibition of Alphavirus Exit

22 Apr 2015

Abstract excerpt

Alphaviruses such as chikungunya virus (CHIKV) and Semliki Forest virus (SFV) are small enveloped RNA viruses that bud from the plasma membrane. Tetherin/BST2 is an interferon-induced host membrane protein that inhibits the release of many enveloped viruses via direct tethering of budded particles to the cell surface. Alphaviruses have highly organized structures and exclude host membrane proteins from the site...

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PMID: 25912717
DOI: 10.3390/v7042147

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