Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of RUNX1 transcriptional function by GATA-1.

Critical reviews in eukaryotic gene expression - 1 Jan 2007

Elagib Kamaleldin E, Goldfarb Adam N

Abstract excerpt

Runt-related transcription factor 1 (RUNX1) and GATA-1 are both transcription factors known to play essential roles in hematopoiesis. Genetic alterations of each are associated with abnormal platelet development, as well as predisposition to leukemia. In addition, in vitro and animal studies indicate that both factors are involved in megakaryopoiesis. We and others have previously shown that RUNX1 and GATA-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to GATA1 Transcription Factor
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Megakaryocytes

Share to Mutation

Share to Phosphorylation

Share to Transcription, Genetic

Source

Identifiers

PMID: 17725493
DOI: 10.1615/critreveukargeneexpr.v17.i4.20

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of RUNX1 transcriptional function by GATA-1.PMID 17725493Read ↗

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiationSemantic proximity Read ↗

GATA transcription factors in hematologic disease.Semantic proximity Read ↗

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiationSemantic proximity Read ↗

Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line modelsSemantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

Distinct mechanisms of regulation of the ITGA6 and ITGB4 genes by RUNX1 in myeloid cells.Semantic proximity Read ↗

GATA1 in normal and malignant hematopoiesis.Semantic proximity Read ↗

Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogenec-KITand amplifies cell proliferationSemantic proximity Read ↗

RUNX family: Regulation and diversification of roles through interacting proteins.Semantic proximity Read ↗

GATA1--a player in normal and leukemic megakaryopoiesis.Semantic proximity Read ↗

GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development.Semantic proximity Read ↗

Normal and transforming functions of RUNX1: A perspectiveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.