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Article

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

20 May 2003

Abstract excerpt

Megakaryocytic and erythroid lineages derive from a common bipotential progenitor and share many transcription factors, most prominently factors of the GATA zinc-finger family. Little is known about transcription factors unique to the megakaryocytic lineage that might program divergence from the erythroid pathway. To identify such factors, we used the K562 system in which megakaryocyte lineage commitment is...

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PMID: 12576332
DOI: 10.1182/blood-2002-09-2708

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