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Article

Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation

10 Sept 2008

Abstract excerpt

The transcription factor GATA-1 participates in programming the differentiation of multiple hematopoietic lineages. In megakaryopoiesis, loss of GATA-1 function produces complex developmental abnormalities and underlies the pathogenesis of megakaryocytic leukemia in Down syndrome. Its distinct functions in megakaryocyte and erythroid maturation remain incompletely understood. In this study, we identified...

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PMID: 18780834
DOI: 10.1182/blood-2008-03-145722

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