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Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteraction

14 May 2024

Abstract excerpt

BACKGROUND/AIMS: The major histocompatibility class II (MHC II) transactivator, known as CIITA, is induced by Interferon gamma (IFN-γ) and plays a well-established role in regulating the expression of class II MHC molecules in antigen-presenting cells. METHODS: Primary human hepatocytes (PHH) were isolated via therapeutic hepatectomy from two donors. The hepatocellular carcinoma (HCC) cell lines HepG2 and Huh7...

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PMID: 38741238
DOI: 10.3350/cmh.2024.0060

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