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Article

IRE1α promotes viral infection by conferring resistance to apoptosis

6 Jun 2017

Abstract excerpt

-deficient cells were generally resistant to the intrinsic pathway of apoptosis through an indirect mechanism involving activation of the nuclease IRE1α. We observed an IRE1α-dependent reduction in the abundance of the proapoptotic microRNA miR-125a and a corresponding increase in the amounts of the members of the antiapoptotic Bcl-2 family. The activation of IRE1α by the hepatitis C virus (HCV) protein NS4B in...

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PMID: 28588082
DOI: 10.1126/scisignal.aai7814

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