Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Kmita Katarzyna, Wirth Christophe, Warnau Judith, Guerrero-Castillo Sergio, Hunte Carola, Hummer Gerhard, Kaila Ville R I, Zwicker Klaus, Brandt Ulrich, Zickermann Volker

Abstract excerpt

Mitochondrial proton-pumping NADH:ubiquinone oxidoreductase (respiratory complex I) comprises more than 40 polypeptides and contains eight canonical FeS clusters. The integration of subunits and insertion of cofactors into the nascent complex is a complicated multistep process that is aided by as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Spin Resonance Spectroscopy
Share to Electron Transport Complex I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis

Share to Mitochondrial Membranes

Share to Molecular Conformation

Share to NADH Dehydrogenase

Share to Spectrophotometry

Source

Open in PubMed Open full text

Identifiers

PMID: 25902503
DOI: 10.1073/pnas.1424353112
PMCID: PMC4426432

Genes

NDUFS6
NDUFA12
NDUFAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25902503-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.PMID 25902503Read ↗

Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease.Semantic proximity Read ↗

Structure of the peripheral arm of a minimalistic respiratory complex I.Semantic proximity Read ↗

Novel insights into the role of Neurospora crassa NDUFAF2, an evolutionarily conserved mitochondrial complex I assembly factor.Semantic proximity Read ↗

Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module.Semantic proximity Read ↗

Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).Semantic proximity Read ↗

Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.Semantic proximity Read ↗

Mitochondrial COA7 is a heme-binding protein involved in the early stages of complex IV assemblySemantic proximity Read ↗

Structural insights into complex I deficiency and assembly from the disease-related <i>ndufs4</i> <sup>-/-</sup> mouseSemantic proximity Read ↗

Biogenesis of NDUFS3-less complex I indicates TMEM126A/OPA7 as an assembly factor of the ND4-moduleSemantic proximity Read ↗

Analysis of NFU-1 metallocofactor binding-site substitutions-impacts on iron-sulfur cluster coordination and protein structure and function.Semantic proximity Read ↗

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates Fe-S complex activitySemantic proximity Read ↗

Assembly of the [4Fe-4S] cluster of NFU1 requires the coordinated donation of two [2Fe-2S] clusters from the scaffold proteins, ISCU2 and ISCA1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.