Structure of the peripheral arm of a minimalistic respiratory complex I.

doi:10.1016/j.str.2021.09.005

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Article

Structure of the peripheral arm of a minimalistic respiratory complex I.

Structure (London, England : 1993) - 6 Jan 2022

Schimpf Johannes, Oppermann Sabrina, Gerasimova Tatjana, Santos Seica Ana Filipa, Hellwig Petra, Grishkovskaya Irina, Wohlwend Daniel, Haselbach David, Friedrich Thorsten

Abstract excerpt

Respiratory complex I drives proton translocation across energy-transducing membranes by NADH oxidation coupled with (ubi)quinone reduction. In humans, its dysfunction is associated with neurodegenerative diseases. The Escherichia coli complex represents the structural minimal form of an energy-converting NADH:ubiquinone oxidoreductase. Here, we report the structure of the peripheral arm of the E. coli complex I...

Topics

Binding Sites
Cryoelectron Microscopy
Electron Transport Complex I
Escherichia coli
Escherichia coli Proteins
Models, Molecular
Mutagenesis, Site-Directed
Mutation
Protein Conformation
Protein Stability
Protein Subunits

Source

Open in PubMed

Identifiers

PMID: 34562374
DOI: 10.1016/j.str.2021.09.005

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