Article

Structural insights into complex I deficiency and assembly from the disease-related <i>ndufs4</i> <sup>-/-</sup> mouse

2023-07-17

Abstract excerpt

Respiratory complex I (NADH:ubiquinone oxidoreductase) is essential for cellular energy production and NAD + homeostasis. Complex I mutations cause neuromuscular, mitochondrial diseases, such as Leigh Syndrome, but their molecular-level consequences remain poorly understood. Here, we use a popular complex I-linked mitochondrial disease model, the ndufs4 -/- mouse, to define the structural, biochemical and functi...

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Literature Corpus work: 0f02eb26-fee6-51fa-bda3-5b1e7531192f
DOI: 10.1101/2023.07.17.549284

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