Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).

Abstract excerpt

Energy converting NADH:ubiquinone oxidoreductase, complex I, is the first enzyme of respiratory chains in most eukaryotes and many bacteria. Mutations in genes encoding subunits of human complex I may lead to its dysfunction resulting in a diverse clinical pattern. The effect of mutations on the protein structure is not known. Here, we focus on mutations R88G, E246K, P252R and E377K that are found in subunit...

Topics

• Electron Transport Complex I
• Binding Sites
• NAD
• Aquifex
• Bacterial Proteins
• Mutation
• Models, Molecular
• Humans
• Crystallography, X-Ray
• Protein Conformation