Article
Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2022
Jackson Thomas D, Crameri Jordan J, Muellner-Wong Linden, Frazier Ann E, Palmer Catherine S, Formosa Luke E, Hock Daniella H, Fujihara Kenji M, Stait Tegan, Sharpe Alice J, Thorburn David R, Ryan Michael T, Stroud David A, Stojanovski Diana
Abstract excerpt
SignificanceMitochondria are double-membraned eukaryotic organelles that house the proteins required for generation of ATP, the energy currency of cells. ATP generation within mitochondria is performed by five multisubunit complexes (complexes I to V), the assembly of which is an intricate process. Mutations in subunits of these complexes, or the suite of proteins that help them assemble, lead to a severe...
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