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Article

Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G.

Invertebrate neuroscience : IN - 1 Jun 2006

Hosie Alastair M, Buckingham Steven D, Hamon Alain, Sattelle David B

Abstract excerpt

The actions of penicillin-G (PCG) on wild-type and mutant Drosophila GABA receptor (RDL) subunits expressed in Xenopus oocytes were studied under two-electrode voltage-clamp. PCG was found to be a non-competitive antagonist of homomeric Drosophila RDL receptors with an IC(50) of 20.41 +/- 1.66 mM at EC(50) GABA. Substitution of a single amino acid (N318R) at the extracellular end of the channel lining region of...

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PMID: 16758255
DOI: 10.1007/s10158-006-0020-4

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