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Article

Actions of picrodendrin antagonists on dieldrin-sensitive and -resistant Drosophila GABA receptors.

British journal of pharmacology - 1 Dec 1996

Hosie A M, Ozoe Y, Koike K, Ohmoto T, Nikaido T, Sattelle D B

Abstract excerpt

1. A series of terpenoid compounds, recently isolated from Picrodendron baccatum, share a picrotoxane skeleton with picrotoxinin, an antagonist of ionotropic GABA receptors. Referred to as picrodendrins, they inhibit the binding of [35S]-tert-butylbicyclophosphorothionate (TBPS) to rat GABAA receptors. Hitherto, their effects on GABA receptors have not been investigated electrophysiologically. Under two-electrode...

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Identifiers

PMID: 8982503
DOI: 10.1111/j.1476-5381.1996.tb16074.x
PMCID: PMC1915789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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