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Article

G3’MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner

29 Jun 2023

Abstract excerpt

Meta-diamides (e.g. broflanilide) and isoxazolines (e.g. fluralaner) are novel insecticides that target the resistant to dieldrin (RDL) subunit of insect γ-aminobutyric acid receptors (GABARs). In this study, we used in silico analysis to identify residues that are critical for the interaction between RDL and these insecticides. Substitution of glycine at the third position (G3') in the third transmembrane domain...

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PMID: 37384781
DOI: 10.1371/journal.pgen.1010814

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