Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels.

British journal of pharmacology - 1 Apr 2012

Islam Robiul, Lynch Joseph W

Abstract excerpt

BACKGROUND AND PURPOSE: Docking studies predict that the insecticides, lindane and fipronil, block GABA(A) receptors by binding to 6' pore-lining residues. However, this has never been tested at any Cys-loop receptor. The neurotoxic effects of these insecticides are also thought to be mediated by GABA(A) receptors, although a recent morphological study suggested glycine receptors mediated fipronil toxicity in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chloride Channels
Share to DNA, Complementary
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insecticides

Share to Mutation

Share to Pyrazoles

Share to Receptors, Glycine

Share to Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22035056
DOI: 10.1111/j.1476-5381.2011.01722.x
PMCID: PMC3423232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels.PMID 22035056Read ↗

Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site.Semantic proximity Read ↗

The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels.Semantic proximity Read ↗

Ion channels: molecular targets of neuroactive insecticidesSemantic proximity Read ↗

Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels.Semantic proximity Read ↗

Functional validation of A2'N mutation of the RDL GABA receptor against fipronil via molecular modeling and genome engineering in drosophila.Semantic proximity Read ↗

Nicotinic acetylcholine receptor modulator insecticides act on diverse receptor subtypes with distinct subunit compositions.Semantic proximity Read ↗

Identification of The Fipronil Resistance Associated Mutations in Nilaparvata lugens GABA Receptors by Molecular Modeling.Semantic proximity Read ↗

Molecular determinants of beta-carboline inhibition of the glycine receptor.Semantic proximity Read ↗

Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor.Semantic proximity Read ↗

Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.Semantic proximity Read ↗

The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl <scp>GABA</scp> receptorSemantic proximity Read ↗

Functional investigation of conserved glutamate receptor subunits reveals a new mode of action of macrocyclic lactones in nematodesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.