Article
Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2015
Torricelli Federica, Mandato Vincenzo Dario, Farnetti Enrico, Abrate Martino, Casali Bruno, Ciarlini Gino, Pirillo Debora, Gelli Maria Carolina, Costagliola Luigi, Nicoli Davide, Palomba Stefano, La Sala Giovanni Battista
Abstract excerpt
The enzyme cyclooxygenase 2 is an inducible enzyme expressed at sites of inflammation and in a variety of malignant solid tumors such as endometrial cancer (EC). In EC patients, its over-expression is correlated with progressive disease and poor prognosis. The expression is encoded by a polymorphic gene, called PTGS2. The aim of the current study was to test the hypothesis that rs5275 polymorphism of PTGS2...
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