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Article

The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2006

Langsenlehner Uwe, Yazdani-Biuki Babak, Eder Tanja, Renner Wilfried, Wascher Thomas C, Paulweber Bernhard, Weitzer Werner, Samonigg Hellmut, Krippl Peter

Abstract excerpt

Cyclooxygenase-2 (COX-2) is involved in carcinogenesis, immune response suppression, apoptosis inhibition, angiogenesis, and tumor cell invasion and metastasis. The gene for COX-2, designated as PTGS2, carries a common polymorphism at position 8473 in the 3'-untranslated region (PTGS2 8473T>C), which has been associated with susceptibility to malignant disease. To investigate the role of this polymorphism for...

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PMID: 16489098
DOI: 10.1158/1078-0432.CCR-05-2055

Genes

PTGS2

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Related research

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The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk.PMID 16489098Read ↗

A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer.Semantic proximity Read ↗

Association of the three common SNPs of cyclooxygenase-2 gene (rs20417, rs689466, and rs5275) with the susceptibility of breast cancer: an updated meta-analysis involving 34,590 subjects.Semantic proximity Read ↗

Lack of association of the cyclooxygenase-2 gene 8473T>C polymorphism with breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.Semantic proximity Read ↗

A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation.Semantic proximity Read ↗

Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population.Semantic proximity Read ↗

Polymorphisms in regulatory regions of cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study.Semantic proximity Read ↗

A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control studySemantic proximity Read ↗

Association between cyclooxygenase-2 (COX-2) 8473 T > C polymorphism and cancer risk: a meta-analysis and trial sequential analysis.Semantic proximity Read ↗

A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a Chinese population.Semantic proximity Read ↗

-765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies.Semantic proximity Read ↗

Association between the 8473T>C polymorphism of PTGS2 and prostate cancer risk: a metaanalysis including 24,716 subjects.Semantic proximity Read ↗

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