Article
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Molecular microbiology - 1 Jul 2015
Petersen Ines, Gabryszewski Stanislaw J, Johnston Geoffrey L, Dhingra Satish K, Ecker Andrea, Lewis Rebecca E, de Almeida Mariana Justino, Straimer Judith, Henrich Philipp P, Palatulan Eugene, Johnson David J, Coburn-Flynn Olivia, Sanchez Cecilia, Lehane Adele M, Lanzer Michael, Fidock David A
Abstract excerpt
The widespread use of chloroquine to treat Plasmodium falciparum infections has resulted in the selection and dissemination of variant haplotypes of the primary resistance determinant PfCRT. These haplotypes have encountered drug pressure and within-host competition with wild-type drug-sensitive parasites. To examine these selective forces in vitro, we genetically engineered P. falciparum to express...
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