Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia.

doi:10.1093/infdis/jiab055

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Article

Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia.

The Journal of infectious diseases - 17 Sept 2021

Shrestha Biraj, Shah Zalak, Morgan Andrew P, Saingam Piyaporn, Chaisatit Chaiyaporn, Chaorattanakawee Suwanna, Praditpol Chantida, Boonyalai Nonlawat, Lertsethtakarn Paphavee, Wojnarski Mariusz, Deutsch-Feldman Molly, Adams Matthew, Sea Darapiseth, Chann Soklyda, Tyner Stuart D, Lanteri Charlotte A, Spring Michele D, Saunders David L, Smith Philip L, Lon Chanthap, Gosi Panita, Sok Somethy, Satharath Prom, Rekol Huy, Lek Dysoley, Vesely Brian A, Lin Jessica T, Waters Norman C, Takala-Harrison Shannon

Abstract excerpt

BACKGROUND: Newly emerged mutations within the Plasmodium falciparum chloroquine resistance transporter (PfCRT) can confer piperaquine resistance in the absence of amplified plasmepsin II (pfpm2). In this study, we estimated the prevalence of co-circulating piperaquine resistance mutations in P. falciparum isolates collected in northern Cambodia from 2009 to 2017. METHODS: The sequence of pfcrt was determined for...

Topics

Animals
Antimalarials
Biomarkers
Cambodia
Drug Resistance
Malaria, Falciparum
Mefloquine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Mutation

Piperazines

Plasmodium falciparum

Prevalence

Protozoan Proteins

Quinolines

Real-Time Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 33528566
DOI: 10.1093/infdis/jiab055
PMCID: PMC8448439

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