Article
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
Nature communications - 17 Aug 2018
Ross Leila S, Dhingra Satish K, Mok Sachel, Yeo Tomas, Wicht Kathryn J, Kümpornsin Krittikorn, Takala-Harrison Shannon, Witkowski Benoit, Fairhurst Rick M, Ariey Frederic, Menard Didier, Fidock David A
Abstract excerpt
The widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid increase in the prevalence of novel mutations in the Plasmodium falciparum chloroquine resistance transporter PfCRT following DHA + PPQ implementation. These mutations occur in parasites harboring the K13 C580Y artemisinin resistance marker....
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