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Article

Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus.

Transplantation proceedings - 1 Jan 2000

Zhao Y, Song M, Guan D, Bi S, Meng J, Li Q, Wang W

Abstract excerpt

OBJECTIVE: CYP3A is the major enzyme responsible for metabolism of the calcineurin inhibitors cyclosporine (CsA) and tacrolimus. Our objective was to determine the relationship between genetic polymorphisms of CYP3A5 with respect to interindividual variability in CsA and tacrolimus pharmacokinetics. METHODS: Kidney transplant recipients receiving CsA (n = 137) or tacrolimus (n = 30) were genotyped for CYP3A5*3...

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Identifiers

PMID: 15808586
DOI: 10.1016/j.transproceed.2005.01.077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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