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Article

Central Role of ULK1 in Type I Interferon Signaling

1 Apr 2015

Abstract excerpt

We provide evidence that the Unc-51-like kinase 1 (ULK1) is activated during engagement of the type I interferon (IFN) receptor (IFNR). Our studies demonstrate that the function of ULK1 is required for gene transcription mediated via IFN-stimulated response elements (ISRE) and IFNγ activation site (GAS) elements and controls expression of key IFN-stimulated genes (ISGs). We identify ULK1 as an upstream regulator...

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PMID: 25892232
DOI: 10.1016/j.celrep.2015.03.056

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