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Article

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

3 Dec 2018

Abstract excerpt

Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). Here, we identify the mixed-lineage kinase domain-like pseudokinase (MLKL) as an ISG in various cancer cell lines. Both type I and type II IFNs increase the expression of MLKL indicating that MLKL up-regulation is a general feature of IFN signaling. IFNγ up-regulates mRNA as well as...

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PMID: 30521981
DOI: 10.1016/j.neo.2018.11.002

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