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Article

Leveraging Multi-ethnic Evidence for Mapping Complex Traits in Minority Populations: An Empirical Bayes Approach.

American journal of human genetics - 7 May 2015

Coram Marc A, Candille Sophie I, Duan Qing, Chan Kei Hang K, Li Yun, Kooperberg Charles, Reiner Alex P, Tang Hua

Abstract excerpt

Elucidating the genetic basis of complex traits and diseases in non-European populations is particularly challenging because US minority populations have been under-represented in genetic association studies. We developed an empirical Bayes approach named XPEB (cross-population empirical Bayes), designed to improve the power for mapping complex-trait-associated loci in a minority population by exploiting...

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Identifiers

PMID: 25892113
DOI: 10.1016/j.ajhg.2015.03.008
PMCID: PMC4570551

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