Article
Effective genetic-risk prediction using mixed models.
American journal of human genetics - 2 Oct 2014
Golan David, Rosset Saharon
Abstract excerpt
For predicting genetic risk, we propose a statistical approach that is specifically adapted to dealing with the challenges imposed by disease phenotypes and case-control sampling. Our approach (termed Genetic Risk Scores Inference [GeRSI]), combines the power of fixed-effects models (which estimate and aggregate the effects of single SNPs) and random-effects models (which rely primarily on whole-genome...
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