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Article

Effect of plasmid replication deregulation via inc mutations on E. coli proteome & simple flux model analysis.

Microbial cell factories - 8 Mar 2015

Meade Jonathan, Bartlow Patrick, Trivedi Ram Narayan, Akhtar Parvez, Ataai Mohammad M, Khan Saleem A, Domach Michael M

Abstract excerpt

When the replication of a plasmid based on sucrose selection is deregulated via the inc1 and inc2 mutations, high copy numbers (7,000 or greater) are attained while the growth rate on minimal medium is negligibly affected. Adaptions were assumed to be required in order to sustain the growth rate. Proteomics indicated that indeed a number of adaptations occurred that included increased expression of ribosomal...

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Identifiers

PMID: 25890349
DOI: 10.1186/s12934-015-0212-x
PMCID: PMC4357208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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