Tuning evolvability via plasmid copy number and regulatory architecture.

Abstract excerpt

Genetic modules are often designed and implemented with inspiration from engineering disciplines. Although this approach can be successful because of the similarities underpinning physical and biochemical systems, it neglects a key factor that affects the performance of living organisms: evolution. Thus, it is crucial to incorporate the impact of inevitable mutations into the design and analysis of genetic...

Topics

• Escherichia coli
• Plasmids
• Gene Dosage
• Evolution, Molecular
• Mutation
• Models, Genetic
• Mutation Rate
• Phenotype
• Gene Expression Regulation, Bacterial
• Gene Regulatory Networks
• Mutagenesis