Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of metabolic stress on genome stability of a synthetic biology chassis Escherichia coli K12 strain.

Microbial cell factories - 22 Jan 2018

Couto Jillian M, McGarrity Anne, Russell Julie, Sloan William T

Abstract excerpt

BACKGROUND: Synthetic organism-based biotechnologies are increasingly being proposed for environmental applications, such as in situ sensing. Typically, the novel function of these organisms is delivered by compiling genetic fragments in the genome of a chassis organism. To behave predictably, these chassis are designed with reduced genomes that minimize biological complexity. However, in these proposed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotechnology
Share to Escherichia coli
Share to Escherichia coli K12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Fitness

Share to Genome, Bacterial

Share to Genomic Instability

Share to Stress, Physiological

Share to Synthetic Biology

Source

Open in PubMed Open full text

Identifiers

PMID: 29357936
DOI: 10.1186/s12934-018-0858-2
PMCID: PMC5776760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of metabolic stress on genome stability of a synthetic biology chassis Escherichia coli K12 strain.PMID 29357936Read ↗

Stability, robustness, and containment: preparing synthetic biology for real-world deployment.Semantic proximity Read ↗

Growth dynamics of 3,909 Escherichia coli single-gene knockouts in rich and minimal media.Semantic proximity Read ↗

Stock culture heterogeneity rather than new mutational variation complicates short-term cell physiology studies of Escherichia coli K-12 MG1655 in continuous culture.Semantic proximity Read ↗

Mitigation of host cell mutations and regime shift during microbial fermentation: a perspective from flux memory.Semantic proximity Read ↗

Greedy reduction of Bacillus subtilis genome yields emergent phenotypes of high resistance to a DNA damaging agent and low evolvability.Semantic proximity Read ↗

Host evolution improves genetic circuit function in complex growth environmentsSemantic proximity Read ↗

The Next Generation of Synthetic Biology Chassis: Moving Synthetic Biology from the Laboratory to the Field.Semantic proximity Read ↗

Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium.Semantic proximity Read ↗

Experimental evolution reveals the genetic basis and systems biology of superoxide stress toleranceSemantic proximity Read ↗

Mutation dynamics and fitness effects followed in single cells.Semantic proximity Read ↗

Adaptation of Escherichia coli to long-term batch culture in various rich media.Semantic proximity Read ↗

Long term adaptation of a microbial population to a permanent metabolic constraint: overcoming thymineless death by experimental evolution of Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.