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Article

Optimization of gene expression through divergent mutational paths.

Cell reports - 23 Feb 2012

Chou Hsin-Hung, Marx Christopher J

Abstract excerpt

Adaptation under similar selective pressure often leads to comparable phenotypes. A longstanding question is whether such phenotypic repeatability entails similar (parallelism) or different genotypic changes (convergence). To better understand this, we characterized mutations that optimized expression of a plasmid-borne metabolic pathway during laboratory evolution of a bacterium. Expressing these pathway genes...

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Identifiers

PMID: 22832162
DOI: 10.1016/j.celrep.2011.12.003
PMCID: PMC3407975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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