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Article

Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition.

Journal of neuroinflammation - 4 Mar 2015

Rojanathammanee Lalida, Floden Angela M, Manocha Gunjan D, Combs Colin K

Abstract excerpt

BACKGROUND: Amyloid β (Aβ) peptide is hypothesized to stimulate microglia to acquire their characteristic proinflammatory phenotype in Alzheimer's disease (AD) brains. The specific mechanisms by which Aβ leads to microglial activation remain an area of interest for identifying attractive molecular targets for intervention. Based upon the fact that microglia express the proinflammatory transcription factor,...

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Identifiers

PMID: 25889879
DOI: 10.1186/s12974-015-0255-2
PMCID: PMC4355356

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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