Article
Quetiapine attenuates glial activation and proinflammatory cytokines in APP/PS1 transgenic mice via inhibition of nuclear factor-κB pathway.
The international journal of neuropsychopharmacology - 31 Oct 2014
Zhu Shenghua, Shi Ruoyang, Li Victor, Wang Junhui, Zhang Ruiguo, Tempier Adrien, He Jue, Kong Jiming, Wang Jun-Feng, Li Xin-Min
Abstract excerpt
BACKGROUND: In Alzheimer's disease, growing evidence has shown that uncontrolled glial activation and neuroinflammation may contribute independently to neurodegeneration. Antiinflammatory strategies might provide benefits for this devastating disease. The aims of the present study are to address the issue of whether glial activation and proinflammatory cytokine increases could be modulated by quetiapine in vivo...
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