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Centromere Plasmid: A New Genetic Tool for the Study of Plasmodium falciparum

30 Mar 2012

Abstract excerpt

The introduction of transgenes into Plasmodium falciparum, a highly virulent human malaria parasite, has been conducted either by single crossover recombination or by using episomal plasmids. However, these techniques remain insufficient because of the low transfection efficiency and the low frequency of recombination. To improve the genetic manipulation of P. falciparum, we developed the centromere plasmid as a...

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PMID: 22479383
DOI: 10.1371/journal.pone.0033326

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