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Article

Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle.

The EMBO journal - 15 Jul 1999

Jensen R B, Gerdes K

Abstract excerpt

The parA locus of plasmid R1 encodes a prokaryotic centromere-like system that mediates genetic stabilization of plasmids by an unknown mechanism. The locus codes for two proteins, ParM and ParR, and a centromere-like DNA region (parC) to which the ParR protein binds. We showed recently that ParR mediates specific pairing of parC-containing DNA molecules in vitro. To obtain further insight into the mechanism of...

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Identifiers

PMID: 10406812
DOI: 10.1093/emboj/18.14.4076
PMCID: PMC1171483

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Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle.PMID 10406812Read ↗

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Silencing of genes flanking the P1 plasmid centromere.Semantic proximity Read ↗

Partitioning of plasmid R1. The ParM protein exhibits ATPase activity and interacts with the centromere-like ParR-parC complex.Semantic proximity Read ↗

Characterization of the double-partitioning modules of R27: correlating plasmid stability with plasmid localization.Semantic proximity Read ↗

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Transcriptional interference by a complex formed at the centromere-like partition site of plasmid P1.Semantic proximity Read ↗

Dissection of the ATPase active site of P1 ParA reveals multiple active forms essential for plasmid partition.Semantic proximity Read ↗

Characterization of chromosomal and megaplasmid partitioning loci in Thermus thermophilus HB27.Semantic proximity Read ↗

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The P1 ParA protein and its ATPase activity play a direct role in the segregation of plasmid copies to daughter cells.Semantic proximity Read ↗

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