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Article

Specificity switching of the P1 plasmid centromere-like site.

The EMBO journal - 1 Apr 1990

Davis M A, Martin K A, Austin S J

Abstract excerpt

The P1 plasmid partition site acts like a centromere, promoting accurate segregation of copies to daughter cells. A 34 bp segment is essential for partition and binds the plasmid ParB protein. Additional sequences act as specificity elements that direct the choice of copies for partition. They include a second ParB binding site and a site for the host integration host factor protein. Sites lacking one or more of...

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Identifiers

PMID: 2182325
DOI: 10.1002/j.1460-2075.1990.tb08201.x
PMCID: PMC551768

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specificity switching of the P1 plasmid centromere-like site.PMID 2182325Read ↗

Silencing of genes flanking the P1 plasmid centromere.Semantic proximity Read ↗

Fine-structure analysis of the P1 plasmid partition site.Semantic proximity Read ↗

Dissection of the ATPase active site of P1 ParA reveals multiple active forms essential for plasmid partition.Semantic proximity Read ↗

Probing the N-terminus of ParB using cysteine-scanning mutagenesis and thiol modification.Semantic proximity Read ↗

Transcriptional interference by a complex formed at the centromere-like partition site of plasmid P1.Semantic proximity Read ↗

Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants.Semantic proximity Read ↗

The P1 ParA protein and its ATPase activity play a direct role in the segregation of plasmid copies to daughter cells.Semantic proximity Read ↗

Altered ParA partition proteins of plasmid P1 act via the partition site to block plasmid propagation.Semantic proximity Read ↗

The role of Par proteins in the active segregation of the P1 plasmid.Semantic proximity Read ↗

Partitioning of plasmid R1. The ParM protein exhibits ATPase activity and interacts with the centromere-like ParR-parC complex.Semantic proximity Read ↗

A model for the evolution of biological specificity: a cross-reacting DNA-binding protein causes plasmid incompatibility.Semantic proximity Read ↗

Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle.Semantic proximity Read ↗

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