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Article

Specificity switching of the P1 plasmid centromere-like site.

The EMBO journal - 1 Apr 1990

Davis M A, Martin K A, Austin S J

Abstract excerpt

The P1 plasmid partition site acts like a centromere, promoting accurate segregation of copies to daughter cells. A 34 bp segment is essential for partition and binds the plasmid ParB protein. Additional sequences act as specificity elements that direct the choice of copies for partition. They include a second ParB binding site and a site for the host integration host factor protein. Sites lacking one or more of...

Topics

Base Sequence
Carrier Proteins
Centromere
Chromosomes
DNA-Binding Proteins
Escherichia coli
Escherichia coli Proteins
Integration Host Factors
Models, Structural
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleotide Mapping

Oligonucleotide Probes

Phenotype

Plasmids

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 2182325
DOI: 10.1002/j.1460-2075.1990.tb08201.x
PMCID: PMC551768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2182325-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Specificity switching of the P1 plasmid centromere-like site.PMID 2182325Read ↗

Silencing of genes flanking the P1 plasmid centromere.Semantic proximity Read ↗

Fine-structure analysis of the P1 plasmid partition site.Semantic proximity Read ↗

Dissection of the ATPase active site of P1 ParA reveals multiple active forms essential for plasmid partition.Semantic proximity Read ↗

Probing the N-terminus of ParB using cysteine-scanning mutagenesis and thiol modification.Semantic proximity Read ↗

Transcriptional interference by a complex formed at the centromere-like partition site of plasmid P1.Semantic proximity Read ↗

Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants.Semantic proximity Read ↗

The P1 ParA protein and its ATPase activity play a direct role in the segregation of plasmid copies to daughter cells.Semantic proximity Read ↗

Altered ParA partition proteins of plasmid P1 act via the partition site to block plasmid propagation.Semantic proximity Read ↗

The role of Par proteins in the active segregation of the P1 plasmid.Semantic proximity Read ↗

Partitioning of plasmid R1. The ParM protein exhibits ATPase activity and interacts with the centromere-like ParR-parC complex.Semantic proximity Read ↗

A model for the evolution of biological specificity: a cross-reacting DNA-binding protein causes plasmid incompatibility.Semantic proximity Read ↗

Mechanism of DNA segregation in prokaryotes: ParM partitioning protein of plasmid R1 co-localizes with its replicon during the cell cycle.Semantic proximity Read ↗

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