Article
ViVaMBC: estimating viral sequence variation in complex populations from illumina deep-sequencing data using model-based clustering.
BMC bioinformatics - 22 Feb 2015
Verbist Bie, Clement Lieven, Reumers Joke, Thys Kim, Vapirev Alexander, Talloen Willem, Wetzels Yves, Meys Joris, Aerssens Jeroen, Bijnens Luc, Thas Olivier
Abstract excerpt
BACKGROUND: Deep-sequencing allows for an in-depth characterization of sequence variation in complex populations. However, technology associated errors may impede a powerful assessment of low-frequency mutations. Fortunately, base calls are complemented with quality scores which are derived from a quadruplet of intensities, one channel for each nucleotide type for Illumina sequencing. The highest intensity of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.