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Article

Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum.

Bioinformatics (Oxford, England) - 1 Jul 2015

Isakov Ofer, Bordería Antonio V, Golan David, Hamenahem Amir, Celniker Gershon, Yoffe Liron, Blanc Hervé, Vignuzzi Marco, Shomron Noam

Abstract excerpt

MOTIVATION: The study of RNA virus populations is a challenging task. Each population of RNA virus is composed of a collection of different, yet related genomes often referred to as mutant spectra or quasispecies. Virologists using deep sequencing technologies face major obstacles when studying virus population dynamics, both experimentally and in natural settings due to the relatively high error rates of these...

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Identifiers

PMID: 25701575
DOI: 10.1093/bioinformatics/btv101
PMCID: PMC4481840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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