Article
High frequencies of de novo CNVs in bipolar disorder and schizophrenia.
Neuron - 22 Dec 2011
Malhotra Dheeraj, McCarthy Shane, Michaelson Jacob J, Vacic Vladimir, Burdick Katherine E, Yoon Seungtai, Cichon Sven, Corvin Aiden, Gary Sydney, Gershon Elliot S, Gill Michael, Karayiorgou Maria, Kelsoe John R, Krastoshevsky Olga, Krause Verena, Leibenluft Ellen, Levy Deborah L, Makarov Vladimir, Bhandari Abhishek, Malhotra Anil K, McMahon Francis J, Nöthen Markus M, Potash James B, Rietschel Marcella, Schulze Thomas G, Sebat Jonathan
Abstract excerpt
While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we reasoned that a contribution of CNVs to mood disorders might be most evident for de novo mutations. We performed a genome-wide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.