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Article

Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring.

Genome biology - 10 Feb 2015

Case Laure K, Wall Emma H, Osmanski Erin E, Dragon Julie A, Saligrama Naresha, Zachary James F, Lemos Bernardo, Blankenhorn Elizabeth P, Teuscher Cory

Abstract excerpt

BACKGROUND: The prevalence of some autoimmune diseases is greater in females compared with males, although disease severity is often greater in males. The reason for this sexual dimorphism is unknown, but it may reflect negative selection of Y chromosome-bearing sperm during spermatogenesis or male fetuses early in the course of conception/pregnancy. Previously, we showed that the sexual dimorphism in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25886764
DOI: 10.1186/s13059-015-0591-7
PMCID: PMC4396973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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